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p(HGNC:CCNE1)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
CCNE1
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

In-Edges 4

bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:CCNE1) View Subject | View Object

Consistent with the notion that cyclin E is targeted by the Parkin ligase complex is the finding that Parkin deficiency leads to accumulation of cyclin E in cultured postmitotic neurons exposed to the glutamatergic excitotoxin kainite and promotes their apoptosis. PubMed:14556719

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:PRKN) association p(HGNC:CCNE1) View Subject | View Object

A rather surprising, recently discovered substrate of Parkin is cyclin E (Staropoli et al., 2003) that is ubiquitinated by the SCF complex that contains Parkin. PubMed:14556719

Appears in Networks:

p(HGNC:PRKN) decreases p(HGNC:CCNE1) View Subject | View Object

Overexpression of Parkin is reported to attenuate cyclin E accumulation and rescue the cells from apoptosis PubMed:14556719

Appears in Networks:

composite(a(PUBCHEM:164810), p(HGNC:PRKN)) decreases p(HGNC:CCNE1) View Subject | View Object

Consistent with the notion that cyclin E is targeted by the Parkin ligase complex is the finding that Parkin deficiency leads to accumulation of cyclin E in cultured postmitotic neurons exposed to the glutamatergic excitotoxin kainite and promotes their apoptosis. PubMed:14556719

Appears in Networks:
Annotations
MeSH
Neurons

Out-Edges 3

p(HGNC:CCNE1) hasVariant p(HGNC:CCNE1, pmod(Ub)) View Subject | View Object

Appears in Networks:

p(HGNC:CCNE1) association p(HGNC:PRKN) View Subject | View Object

A rather surprising, recently discovered substrate of Parkin is cyclin E (Staropoli et al., 2003) that is ubiquitinated by the SCF complex that contains Parkin. PubMed:14556719

Appears in Networks:

p(HGNC:CCNE1) positiveCorrelation bp(GO:"neuron apoptotic process") View Subject | View Object

Consistent with the notion that cyclin E is targeted by the Parkin ligase complex is the finding that Parkin deficiency leads to accumulation of cyclin E in cultured postmitotic neurons exposed to the glutamatergic excitotoxin kainite and promotes their apoptosis. PubMed:14556719

Appears in Networks:
Annotations
MeSH
Neurons

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.