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rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069)))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Appears in Networks 1

APP processing in Alzheimer's disease v1.0.1

APP processing in Alzheimer's disease

In-Edges 1

a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069))) View Subject | View Object

In addition to secretases, caspases (predominantly caspase- 3) can directly cleave APP at position Asp664 (based on the APP695 sequence) within the cytoplasmic tail during apoptosis to release a fragment containing the last 31 amino acids of APP (called C31) PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Neurons

Out-Edges 2

rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069))) hasReactant p(HGNC:APP) View Subject | View Object

Appears in Networks:

rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069))) hasProduct a(HBP:HBP00069) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.