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bp(GO:"protein K63-linked ubiquitination")

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Entity

Name
protein K63-linked ubiquitination
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 3

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection v1.0.0

In-Edges 2

complex(p(HGNC:UCHL1), p(HGNC:UCHL1)) increases bp(GO:"protein K63-linked ubiquitination") View Subject | View Object

It has been reported recently that while the monomeric form of UCH-L1 catalyzes deubiquitination, the dimers display a ubiquitin ligase activity that generates ubiquitin-K63 bonds (Liu et al., 2002). PubMed:14556719

Appears in Networks:

a(GO:"neurofibrillary tangle") association bp(GO:"protein K63-linked ubiquitination") View Subject | View Object

For example, immunocytochemistry showing the presence of K63- linked polyubiquitin in a fraction of the NFTs in AD cortex (Paine et al. 2009) suggests an active involvement of autophagy in the mechanism of AD. PubMed:22908190

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

Out-Edges 5

bp(GO:"protein K63-linked ubiquitination") increases act(complex(GO:"proteasome complex")) View Subject | View Object

Conjugation to other Lys residues, Lys63 for example, serves nonproteolytic functions of the system, such as activation of transcription PubMed:14556719

Appears in Networks:

bp(GO:"protein K63-linked ubiquitination") association a(GO:"neurofibrillary tangle") View Subject | View Object

For example, immunocytochemistry showing the presence of K63- linked polyubiquitin in a fraction of the NFTs in AD cortex (Paine et al. 2009) suggests an active involvement of autophagy in the mechanism of AD. PubMed:22908190

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

bp(GO:"protein K63-linked ubiquitination") increases bp(GO:autophagy) View Subject | View Object

Specifically, it is suggested that K63-linked polyubiquitin chains recruit p62 and HDAC6 providing a signal for autophagic degradation [92,93]. PubMed:18930136

Appears in Networks:

bp(GO:"protein K63-linked ubiquitination") increases act(p(HGNC:SQSTM1)) View Subject | View Object

Specifically, it is suggested that K63-linked polyubiquitin chains recruit p62 and HDAC6 providing a signal for autophagic degradation [92,93]. PubMed:18930136

Appears in Networks:

bp(GO:"protein K63-linked ubiquitination") increases act(p(HGNC:HDAC6)) View Subject | View Object

Specifically, it is suggested that K63-linked polyubiquitin chains recruit p62 and HDAC6 providing a signal for autophagic degradation [92,93]. PubMed:18930136

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.