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composite(a(CHEBI:"amyloid-beta"), a(CHEBI:nicotine))

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Components

Appears in Networks 1

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

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Out-Edges 3

composite(a(CHEBI:"amyloid-beta"), a(CHEBI:nicotine)) hasComponent a(CHEBI:nicotine) View Subject | View Object

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composite(a(CHEBI:"amyloid-beta"), a(CHEBI:nicotine)) hasComponent a(CHEBI:"amyloid-beta") View Subject | View Object

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composite(a(CHEBI:"amyloid-beta"), a(CHEBI:nicotine)) increases act(a(HBP:"alpha-4 beta-2 nAChR")) View Subject | View Object

Arora et al. (2013) investigated, in a cellular system, the effect of prolonged Abeta exposure on nAChR function. The rodent neuroblastoma cell line NG108-15 was transfected with alpha4beta2 nAChRs and treated for three days with 100 nM Abeta. The following acute stimulation with Abeta and nicotine led to receptor activation that caused a perturbation of intracellular calcium homeostasis followed by mitochondrial dysfunction and increased oxidative stress (Arora et al., 2013) PubMed:25514383

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.