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Appears in Networks 4

In-Edges 4

a(PUBCHEM:135316034) increases p(HGNC:HSPB8) View Subject | View Object

HSPB8, induced 19-fold, is a heat shock protein that forms a complex with BAG3 (also induced 1.43-fold). PubMed:22020111

a(HBP:"amyloid-beta aggregates") association p(HGNC:HSPB8) View Subject | View Object

The importance of sHSPs in disease was originally noted from the observations that HSPB1 and CRYAB were overexpressed in AD brains (Shinohara et al., 1993; Renkawek et al., 1994a,b) and HSPB1, CRYAB, HSPB6 and HSPB8 were associated with AD plaques (Shao et al., 2012). PubMed:27491084

p(HGNC:EIF2A) association p(HGNC:HSPB8) View Subject | View Object

Moreover, HSP22 stimu- lates autophagy-mediated degradation of protein aggregates in an eIF2α-dependent manner [30]. PubMed:24563850

Out-Edges 4

p(HGNC:HSPB8) increases complex(p(HGNC:BAG3), p(HGNC:HSPB8)) View Subject | View Object

HSPB8, induced 19-fold, is a heat shock protein that forms a complex with BAG3 (also induced 1.43-fold). PubMed:22020111

p(HGNC:HSPB8) association a(HBP:"amyloid-beta aggregates") View Subject | View Object

The importance of sHSPs in disease was originally noted from the observations that HSPB1 and CRYAB were overexpressed in AD brains (Shinohara et al., 1993; Renkawek et al., 1994a,b) and HSPB1, CRYAB, HSPB6 and HSPB8 were associated with AD plaques (Shao et al., 2012). PubMed:27491084

p(HGNC:HSPB8) association p(HGNC:EIF2A) View Subject | View Object

Moreover, HSP22 stimu- lates autophagy-mediated degradation of protein aggregates in an eIF2α-dependent manner [30]. PubMed:24563850

p(HGNC:HSPB8) increases bp(GO:"chaperone-mediated autophagy") View Subject | View Object

Moreover, HSP22 stimu- lates autophagy-mediated degradation of protein aggregates in an eIF2α-dependent manner [30]. PubMed:24563850

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.