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complex(a(CHEBI:nicotine), p(HGNC:CHRNA7))

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Components

Appears in Networks 2

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0

Nicotinic Receptor Abnormalities of Alzheimer’s Disease: Therapeutic Implications v1.0.0

In-Edges 0

Out-Edges 5

complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) hasComponent a(CHEBI:nicotine) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) hasComponent p(HGNC:CHRNA7) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"ERK1 and ERK2 cascade") View Subject | View Object

In studies on SH-SY5Y cells and cultured rat hippocampal neurons, nicotine, acting through alpha7 nAChRs, results in the activation of ERK-1/2 pathways dependent upon calcium and protein kinase A (Dajas-Bailador et al., 2002b). In addition, the alpha7-specific agonist GTS-21 promotes ERK-1/2 phosphorylation, but not that of c-jun N-terminal kinase (JNK) or p38 (Ren et al., 2005). PubMed:19293145

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Annotations
Experimental Factor Ontology (EFO)
SH-SY5Y

complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases act(p(FPLX:JNK)) View Subject | View Object

Nicotine may regulate the neuroprotective secretion of TNFalpha by microglia through enhancement of lowlevel TNF secretion and suppression of lipopolysaccharide- induced TNFalpha secretion (Suzuki et al., 2006; Park et al., 2007) via alpha7-dependent activation of JNK and MAPK pathways. PubMed:19293145

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complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade") View Subject | View Object

Nicotine may regulate the neuroprotective secretion of TNFalpha by microglia through enhancement of lowlevel TNF secretion and suppression of lipopolysaccharide- induced TNFalpha secretion (Suzuki et al., 2006; Park et al., 2007) via alpha7-dependent activation of JNK and MAPK pathways. PubMed:19293145

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.