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p(HGNC:BACE1, var("p.?"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
BACE1
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Identification of a novel aspartic protease (Asp 2) as beta-secretase v1.0.0

In-Edges 1

p(HGNC:BACE1) hasVariant p(HGNC:BACE1, var("p.?")) View Subject | View Object

Appears in Networks:

Out-Edges 1

p(HGNC:BACE1, var("p.?")) causesNoChange sec(a(HBP:"sAPP-beta")) View Subject | View Object

However, expression of either of the Asp 2 mutants does not produce the increase in the secretion of sAPPb (Fig. 2b) seen for wild-type Asp 2. In contrast to this clear effect on sAPPb, Asp 2 has no effect on the secretion of soluble APPa or on full-length APP in the cell (data not shown). PubMed:10656250

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.