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a(PUBCHEM:25096749)

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Entity

Name
25096749
Namespace
PUBCHEM
Namespace Version
None
Pattern
^\d+$

Appears in Networks 1

Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity v1.0.0

In-Edges 0

Out-Edges 2

a(PUBCHEM:25096749) increases bp(GO:locomotion) View Subject | View Object

We then applied, in the 96-well liquid culture format, the two most promising hit compounds obtained in a mammalian cell model of Tau toxicity (57), namely the phenylthiazolyl- hydrazide derivatives Bsc3094 and bb14, and observed a similar amelioration effect in locomotion (Supplementary Ma- terial, Fig. S6B). PubMed:22611162

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Annotations
MeSH
Tauopathies

a(PUBCHEM:25096749) decreases a(HBP:"Tau aggregates") View Subject | View Object

BSc3094 resulted in 40% decrease in the detergent-insoluble Tau (FA fraction) in pro-aggregant animals, PubMed:22611162

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.