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  3. complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I"))

complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Components

Appears in Networks 1

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

In-Edges 0

Out-Edges 5

complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases p(FPLX:ADCY) View Subject | View Object

Activation of Gαi coupled muscarinic receptors leads to inhibition of adenylyl cyclase and reduction of cyclic adenosine monophosphate (cAMP) levels, promoting inhibition of voltage-gated Ca2+ channels and, thus, diminishing cell excitability PubMed:26813123

Appears in Networks:

complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) hasComponent p(HGNC:CHRM4) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) hasComponent p(INTERPRO:"G-protein alpha subunit, group I") View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP") View Subject | View Object

Activation of Gαi coupled muscarinic receptors leads to inhibition of adenylyl cyclase and reduction of cyclic adenosine monophosphate (cAMP) levels, promoting inhibition of voltage-gated Ca2+ channels and, thus, diminishing cell excitability PubMed:26813123

Appears in Networks:

complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases act(a(MESH:"Calcium Channels")) View Subject | View Object

Activation of Gαi coupled muscarinic receptors leads to inhibition of adenylyl cyclase and reduction of cyclic adenosine monophosphate (cAMP) levels, promoting inhibition of voltage-gated Ca2+ channels and, thus, diminishing cell excitability PubMed:26813123

Appears in Networks:

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.