1. Catalog
  2. Nodes
  3. bp(GO:"microtubule depolymerization")

bp(GO:"microtubule depolymerization")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
microtubule depolymerization
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 3

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Axonal Transport, Tau Protein, and Neurodegeneration in Alzheimer’s Disease v1.0.0

Alzheimer’s disease and the autophagic-lysosomal system v1.0.0

In-Edges 3

p(HGNC:KIF2A, pmod(Ph)) negativeCorrelation bp(GO:"microtubule depolymerization") View Subject | View Object

These findings indicate that TTBK2 with EB1/3 phosphorylates KIF2A and antagonizes KIF2A-induced depolymerization at MT plus ends for cell migration. PubMed:26323690

Appears in Networks:

p(HGNC:MAPT) decreases bp(GO:"microtubule depolymerization") View Subject | View Object

An important function of tau protein involves the stabilization and spacing of microtubules, proba- bly by linking to a number of tubulin subunits, thereby preventing or slowing microtubule depoly- merization (Drubin and Kirschner, 1986). PubMed:12428809

Appears in Networks:

p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases bp(GO:"microtubule depolymerization") View Subject | View Object

However, when tau becomes hyperphosphorylated, it detaches from microtubules and aggregates, resulting in depolymerization of microtubules and formation of insoluble tau deposits [40] PubMed:29758300

Appears in Networks:

Out-Edges 1

bp(GO:"microtubule depolymerization") negativeCorrelation p(HGNC:KIF2A, pmod(Ph)) View Subject | View Object

These findings indicate that TTBK2 with EB1/3 phosphorylates KIF2A and antagonizes KIF2A-induced depolymerization at MT plus ends for cell migration. PubMed:26323690

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.