1. Catalog
  2. Nodes
  3. complex(p(HGNC:FYN), p(MGI:Mapt))

complex(p(HGNC:FYN), p(MGI:Mapt))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Components

Appears in Networks 1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 1

p(HBP:"Tau epitope, AT8") increases complex(p(HGNC:FYN), p(MGI:Mapt)) View Subject | View Object

This result is supported by recent studies showing that the interaction between Fyn and tau is regulated through tau phosphorylation at the AT8 site, increasing tau-Fyn interaction by 42-fold after tau is phosphorylated or bearing a phosphomimetic mutation at the AT8 site (63). In our experiments, tau phosphorylation at AT8 is strongly up-regulated through the activation of NMDA receptors (Fig. 3), suggesting that NMDA receptor activation could massively enhance the interaction between tau and Fyn. PubMed:22833681

Appears in Networks:
Annotations
Uberon
hippocampal formation

Out-Edges 2

complex(p(HGNC:FYN), p(MGI:Mapt)) hasComponent p(HGNC:FYN) View Subject | View Object

Appears in Networks:

complex(p(HGNC:FYN), p(MGI:Mapt)) hasComponent p(MGI:Mapt) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.