r(HGNC:APP)

Entity

Name

APP

Namespace

hgnc

Namespace Version

20180906

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

In addition to Abeta acting upon nAChRs, nAChRs in turn regulate Abeta secretion. Nicotine or epibatidine applied to the human SHEP1 cell line stably transfected with human alpha4beta2 nAChRs and human APP decreases the secretion and intracellular accumulation of Abeta without significantly affecting the APP mRNA, suggesting that these effects are post-translational (Nie et al., 2007). PubMed:19293145

Single cell gene array studies have shown that synaptic transcripts are selectively downregulated in CBF neurons in AD, with significant reductions in synaptophysin and synaptotagmin but not synaptobrevin or SNAP29 mRNA [134,135]. Intriguingly, synaptotagmin function is related to vesicle-presynaptic membrane fusion and neurotransmitter release, suggesting that perturbations in presynaptic vesicle trafficking comprise a common event in vulnerable neuronal populations in AD. In contrast to synaptic transcripts, mRNAs encoding APP and Notch were unchanged between control and AD subjects, whereas acid hydrolase cathepsin D mRNA was upregulated in AD [134–136]. PubMed:18986241