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bp(GO:proteolysis)

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Entity

Name
proteolysis
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 4

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy v1.0.1

Alzheimer’s disease and the autophagic-lysosomal system v1.0.0

In-Edges 2

p(HGNC:UBA3) association bp(GO:proteolysis) View Subject | View Object

It appears that E3s play a key role in the ubiquitin-mediated proteolytic cascade since they serve as the specific substrate recognition factors of the system PubMed:14556719

Appears in Networks:

bp(GO:"vacuolar acidification") increases bp(GO:proteolysis) View Subject | View Object

Mutations in PS1 were shown to impair the acidification of lysosomes, which is necessary for activating the proteolytic enzymes in this compartment. Improper acidification and impaired proteolysis of substrates would compromise the autophagy system and result in the accumulation of AVs as described above. PubMed:24027553

Appears in Networks:
Annotations
Text Location
Review

Out-Edges 3

bp(GO:proteolysis) association p(HGNC:UBA3) View Subject | View Object

It appears that E3s play a key role in the ubiquitin-mediated proteolytic cascade since they serve as the specific substrate recognition factors of the system PubMed:14556719

Appears in Networks:

bp(GO:proteolysis) increases deg(a(CHEBI:"amyloid-beta")) View Subject | View Object

The proteolytic degradation is also a major pathway of Aβ clearance PubMed:29626319

Appears in Networks:

bp(GO:proteolysis) decreases bp(GO:"neuron death") View Subject | View Object

With neurons profoundly relying on macroautophagy for clearance of toxic protein aggregates, impairment in the proteolytic systems ultimately results in progressive neuronal death, a common feature in several neurodegenerative diseases [27]. PubMed:29758300

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.