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  3. complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family"))

complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family"))

Appears in Networks 1

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies v1.0.0

In-Edges 2

a(CHEBI:polyphenol) decreases complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family")) View Subject | View Object

Using high-throughput screening against the J-protein-stimulated ATPase activity of an Hsp70, we also found polyphenols that selectively block J-stimulated activities by interfering with J-protein recruitment to the Hsp70 complex [72]. PubMed:21882945

Appears in Networks:

a(PUBCHEM:1056) regulates complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family")) View Subject | View Object

For example, we found that dihydropyrimidine-based molecules can either force the association of a prokaryotic Hsp70 with its J-protein partner or, with a relatively modest change in chemical structure, related compounds could block this contact [73]. PubMed:21882945

Appears in Networks:

Out-Edges 2

complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family")) hasComponent p(INTERPRO:"Chaperone J-domain superfamily") View Subject | View Object

Appears in Networks:

complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family")) hasComponent p(INTERPRO:"Heat shock protein 70 family") View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.