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a(PUBCHEM:33334)

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Entity

Name
33334
Namespace
PUBCHEM
Namespace Version
None
Pattern
^\d+$

Appears in Networks 1

Amyloid-Binding Alcohol Dehydrogenase (ABAD) Inhibitors for the Treatment of Alzheimer’s Disease v1.0.0

In-Edges 0

Out-Edges 2

a(PUBCHEM:33334) decreases complex(p(HGNC:APP), p(HGNC:HSD17B10)) View Subject | View Object

Frentizole, an FDA approved immunosuppressant drug, was identified as an Aβ-ABAD interaction inhibitor (IC 50 = 200 M) using an ELISA-based screening assay. PubMed:30444369

Appears in Networks:
Annotations
MeSH
Neurons

a(PUBCHEM:33334) decreases act(p(HGNC:CSNK1A1)) View Subject | View Object

Screening previously synthesized frentizole derivatives for their efficiency to inhibit CK1 activity as well as ABAD, identified compound 13 which possessed an ABAD IC 50 = 1.67 µM, the most potent inhibitor of this chemotype identified to date. PubMed:30444369

Appears in Networks:
Annotations
MeSH
Neurons

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.