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p(HGNC:PTPRC)

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Entity

Name
PTPRC
Namespace
hgnc
Namespace Version
20190224
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/hgnc-names.belns

Appears in Networks 1

Chronic Anatabine Treatment Reduces Alzheimer ’ s Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD v1.0.0

In-Edges 2

a(CHEBI:"amyloid-beta") increases p(HGNC:PTPRC) View Subject | View Object

A significant increase in CD45 immunopositive microglia/macrophage was observed in the cortex of Tg PS1/APPswe mice compared to wild- type mice (CD45 immunonegative) (Fig 5C). PubMed:26010758

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Cell Ontology (CL)
microglial cell
MeSH
Cerebral Cortex
MeSH
Alzheimer Disease

a(CHEBI:Anatabine) decreases p(HGNC:PTPRC) View Subject | View Object

However, we observed a significant reduction in CD45 immunopositive microglia/macrophage in Tg PS1/APPswe mice receiving anatabine at a dosage of 10 and 20 mg/Kg/Day compared to Tg PS1/APPswe mice receiving regular drink- ing water (Fig 5C and 5D). PubMed:26010758

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
Cell Ontology (CL)
microglial cell
MeSH
Cerebral Cortex
MeSH
Alzheimer Disease

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.