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complex(GO:"NADPH oxidase complex")

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Entity

Name
NADPH oxidase complex
Namespace
go
Namespace Version
20190207
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/a5b84013a08880975ca84f40999e4404b14a97e2/external/go-names.belns

Appears in Networks 1

Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability v1.0.0

In-Edges 2

p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(complex(GO:"NADPH oxidase complex")) View Subject | View Object

We indeed found that there is an overexpression (w15%) of Nox1 protein (a component of NADPH oxidase complex) by Western blot, suggesting the role of NADPH oxidase complex as a potential source of ROS PubMed:28528849

Appears in Networks:

p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(complex(GO:"NADPH oxidase complex")) View Subject | View Object

These findings suggest that the ROS production induced by extracellular TauRDΔK oligomers might cause the activation of NADPH oxidase complex PubMed:28528849

Appears in Networks:

Out-Edges 2

act(complex(GO:"NADPH oxidase complex")) increases a(CHEBI:"reactive oxygen species") View Subject | View Object

We indeed found that there is an overexpression (w15%) of Nox1 protein (a component of NADPH oxidase complex) by Western blot, suggesting the role of NADPH oxidase complex as a potential source of ROS PubMed:28528849

Appears in Networks:

act(complex(GO:"NADPH oxidase complex")) increases a(CHEBI:"reactive oxygen species") View Subject | View Object

These findings suggest that the ROS production induced by extracellular TauRDΔK oligomers might cause the activation of NADPH oxidase complex PubMed:28528849

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.