Evidences p(HGNC:LRP1) to complex(a(CHEBI:heme), p(HGNC:HPX))

Normally, haemopexin safely transports haem away from the vessel wall to ligate LRP1 (also termed CD91) on hepatocytes and macrophages, where the haem–haemopexin complex is endocytosed and haem is degraded intracellularly (Hvidberg et al, 2005).

Free heme in blood is sequestered by hemopexin (Hpx) [23,24] and the Hpx-heme complex is cleared from the circulation by the hepatocyte receptor CD91 [25].

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