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p(HGNC:PSMD14)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
PSMD14
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Perilous journey: a tour of the ubiquitin–proteasome system v1.0.0

In-Edges 1

tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) increases act(p(HGNC:PSMD14)) View Subject | View Object

Thus, the binding of substrate to the 26S and its concomitant translocation into the 20S results in the activation of Rpn11 through a conformational change. PubMed:24457024

Appears in Networks:

Out-Edges 3

p(HGNC:PSMD14) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) View Subject | View Object

Second, Rpn11/Poh1 (also known as Psmd14) is a subunit in the 19S regulatory particle that cleaves the entire, intact ubiquitin chain from the protein substrate [71,72]. PubMed:24457024

Appears in Networks:

p(HGNC:PSMD14) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) View Subject | View Object

This observation suggests that chain binding and cleavage from the protein substrate are tightly coordinated by the proteasome, and may help to prevent situations such as premature chain cleavage by Rpn11, which could result in the release of the substrate before it becomes actively engaged to the proteasome. PubMed:24457024

Appears in Networks:

act(p(HGNC:PSMD14)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) View Subject | View Object

This activity promotes both the recycling of chains back into the free cellular pool of ubiquitin and creates space for the protein substrate to enter the 20S core. PubMed:24457024

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.