bp(GO:"synaptic signaling")

Entity

Name

synaptic signaling

Namespace

go

Namespace Version

20180828

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/go-names.belns

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage from Shafiei et al., 2017

It has been postulated that soluble or small oligomeric forms of Ab have deleterious effects in the brain, inducing impaired synaptic function and promoting neuronal degeneration [5]. PubMed:21718217

It has been postulated that soluble or small oligomeric forms of Ab have deleterious effects in the brain, inducing impaired synaptic function and promoting neuronal degeneration [5]. PubMed:21718217

While evidence has linked FTD with parkinsonism in patients to tau mutations on chromosome 17 (FTDP-17), implying that tau dysfunction alone can cause neurodegeneration (Reed et al., 2001), studies in animal models have shown that overexpression of tau can lead to cell death (Lee et al., 2001; Tanemura et al., 2001, 2002; Tatebayashi et al., 2002) and exhibit behavioral abnormalities and synaptic dysfunction without the presence of NFTs (Wittmann et al., 2001; Andorfer et al., 2003; Santacruz et al., 2005; Spires et al., 2006; Berger et al., 2007; Yoshiyama et al., 2007; Cowan et al., 2010) PubMed:28420982

Aberrant phosphorylation and aggregation of Tau have been linked to axonal transport problems, synaptic malfunction and degeneration (6). PubMed:22611162

Resistance to aldicarb can arise from either a pre- or a post-synaptic perturbation, whereas resistance to levamisole typically indicates a post-synaptic defect (50). Animals of the pro-aggregant strain displayed a mild resist- ance to aldicarb, producing a paralysis profile intermediate between the sensitive wild-type N2 and the resistant rab-3(js49) strain, which we used as controls (Fig. 5A). PubMed:22611162

Aberrant phosphorylation and aggregation of Tau have been linked to axonal transport problems, synaptic malfunction and degeneration (6). PubMed:22611162