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  3. p(HGNC:MAPT, var("p.Gln124*"))

p(HGNC:MAPT, var("p.Gln124*"))

Equivalencies: 0 | Classes: 1 | Children: 0 | Explore

Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 3

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, var("p.Gln124*")) View Subject | View Object

Appears in Networks:

act(p(HGNC:VASH1)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*")) View Subject | View Object

In agreement with this possibility, the investigation of another posttranslational modification of tubulin, detyrosination, which is also representative of a stable population of microtubules, revealed that it was significantly increased with Gln124-Tau when compared to FL-Tau PubMed:25974414

Appears in Networks:
Annotations
Uberon
cerebral cortex
Confidence
Medium

act(p(HGNC:VASH2)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*")) View Subject | View Object

In agreement with this possibility, the investigation of another posttranslational modification of tubulin, detyrosination, which is also representative of a stable population of microtubules, revealed that it was significantly increased with Gln124-Tau when compared to FL-Tau PubMed:25974414

Appears in Networks:
Annotations
Uberon
cerebral cortex
Confidence
Medium

Out-Edges 5

p(HGNC:MAPT, var("p.Gln124*")) isA p(HGNC:MAPT) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, var("p.Gln124*")) increases p(FPLX:Tubulin, pmod(Ac)) View Subject | View Object

Regarding the effect of N-terminally truncated Tau, the Met11-Tau fragment showed the same properties as FL-Tau while Gln124-Tau was associated with a markedly increased level of acetylated tubulin compared to FL-Tau. PubMed:25974414

Appears in Networks:
Annotations
Uberon
cerebral cortex

p(HGNC:MAPT, var("p.Gln124*")) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) View Subject | View Object

In agreement with this possibility, the investigation of another posttranslational modification of tubulin, detyrosination, which is also representative of a stable population of microtubules, revealed that it was significantly increased with Gln124-Tau when compared to FL-Tau PubMed:25974414

Appears in Networks:
Annotations
Uberon
cerebral cortex

p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH1)) View Subject | View Object

In agreement with this possibility, the investigation of another posttranslational modification of tubulin, detyrosination, which is also representative of a stable population of microtubules, revealed that it was significantly increased with Gln124-Tau when compared to FL-Tau PubMed:25974414

Appears in Networks:
Annotations
Uberon
cerebral cortex
Confidence
Medium

p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH2)) View Subject | View Object

In agreement with this possibility, the investigation of another posttranslational modification of tubulin, detyrosination, which is also representative of a stable population of microtubules, revealed that it was significantly increased with Gln124-Tau when compared to FL-Tau PubMed:25974414

Appears in Networks:
Annotations
Uberon
cerebral cortex
Confidence
Medium

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.