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path(MESH:D009410)

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Entity

Name
D009410
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh.belns

Appears in Networks 1

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

In-Edges 2

bp(MESH:D018384) association path(MESH:D009410) View Subject | View Object

A third downstream mediator is the PLCgamma pathway [94,95]. PLCgamma pathway dysfunction may play a role in Ca2+-mediated cellular degeneration in aging and disease by affecting oxidative stress systems [96]. PubMed:18986241

Appears in Networks:
Annotations
MeSH
Cognitive Dysfunction

r(HGNC:CHRNA7) increases path(MESH:D009410) View Subject | View Object

Despite a putative beneficial role for increased CBF neuron alpha7 nAChR expression in AD (that may also be relevant to smoking behavior), evidence suggests that increased alpha7 nAChR expression contributes to cellular degeneration. Notably, alpha7 nAChR binds and/or interacts with APP and Ab peptides [123–125]. Increased NB neuronal alpha7 nAChR expression may arise as a compensatory response that is offset by aberrant Ab-alpha7 nAChR interactions, leading to cholinergic dysfunction. PubMed:18986241

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease
MeSH
Cognitive Dysfunction

Out-Edges 1

path(MESH:D009410) association bp(MESH:D018384) View Subject | View Object

A third downstream mediator is the PLCgamma pathway [94,95]. PLCgamma pathway dysfunction may play a role in Ca2+-mediated cellular degeneration in aging and disease by affecting oxidative stress systems [96]. PubMed:18986241

Appears in Networks:
Annotations
MeSH
Cognitive Dysfunction

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.