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a(CHEBI:"L-glutamate(2-)")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
L-glutamate(2-)
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0

In-Edges 4

a(CHEBI:genistein) decreases act(a(CHEBI:"L-glutamate(2-)")) View Subject | View Object

Genistein, a phytoestrogen, protects SH-SY5Y cells (Bang et al., 2004) as well as cultured hippocampal neurons (Zeng et al., 2004) from Abeta toxicity. However, in addition to its action on estrogen receptors, genistein is also a general tyrosine kinase inhibitor that protects cultured neurons from L-glutamate toxicity (Kajta et al., 2007). PubMed:19293145

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
SH-SY5Y

act(a(MESH:"Cholinesterase Inhibitors")) decreases act(a(CHEBI:"L-glutamate(2-)")) View Subject | View Object

Likewise, blocking the PI3K-AKT pathway inhibits the protective effects of AChE inhibitors on neuroblastoma cells or neuronal cells against Abeta (Arias et al., 2005) or L-glutamate neurotoxicity (Takada-Takatori et al., 2006). In all these studies, protection was also inhibited by nAChR blockers, suggesting that these effects are mediated by nAChRs. PubMed:19293145

Appears in Networks:
Annotations
MeSH
Neurons

act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:"L-glutamate(2-)")) View Subject | View Object

For example, alpha4-specific agonists protect porcine small retinal ganglion cells against L-glutamate toxicity (Thompson et al., 2006), whereas alpha7 nAChRs protect large retinal ganglion cells (Wehrwein et al., 2004) against L-glutamate toxicity. PubMed:19293145

Appears in Networks:
Annotations
MeSH
Retinal Ganglion Cells

act(p(HGNC:CHRNA4)) decreases act(a(CHEBI:"L-glutamate(2-)")) View Subject | View Object

For example, alpha4-specific agonists protect porcine small retinal ganglion cells against L-glutamate toxicity (Thompson et al., 2006), whereas alpha7 nAChRs protect large retinal ganglion cells (Wehrwein et al., 2004) against L-glutamate toxicity. PubMed:19293145

Appears in Networks:
Annotations
MeSH
Retinal Ganglion Cells

Out-Edges 2

act(a(CHEBI:"L-glutamate(2-)")) increases path(HBP:neurotoxicity) View Subject | View Object

For example, alpha4-specific agonists protect porcine small retinal ganglion cells against L-glutamate toxicity (Thompson et al., 2006), whereas alpha7 nAChRs protect large retinal ganglion cells (Wehrwein et al., 2004) against L-glutamate toxicity. PubMed:19293145

Appears in Networks:
Annotations
MeSH
Retinal Ganglion Cells

act(a(CHEBI:"L-glutamate(2-)")) increases path(HBP:neurotoxicity) View Subject | View Object

Genistein, a phytoestrogen, protects SH-SY5Y cells (Bang et al., 2004) as well as cultured hippocampal neurons (Zeng et al., 2004) from Abeta toxicity. However, in addition to its action on estrogen receptors, genistein is also a general tyrosine kinase inhibitor that protects cultured neurons from L-glutamate toxicity (Kajta et al., 2007). PubMed:19293145

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
SH-SY5Y

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.