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Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 2

a(CHEBI:"lead diacetate") increases p(RGD:Ppp1ca) View Subject | View Object

PP2A expression decreased, whereas, PP1 and PP5 expression increased in lead-exposed rats. These results demonstrate that early postnatal exposure to lead decrease PP2A expression and induce tau hyperphosphorylation at several serine and threonine residues. PubMed:23134599

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act(p(RGD:Cdk5)) directlyDecreases act(p(RGD:Ppp1ca)) View Subject | View Object

In NGF-exposed PC12 cells, Egr-1 activates Cdk5 to promote phosphorylation of tau and inactivates PP1 via phosphorylation. Cdk5 phosphorylates Ser(396/404) directly. By phosphorylating and inactivating PP1, Cdk5 promotes tau phosphorylation at Ser(262) indirectly. PubMed:21489990

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Experimental Factor Ontology (EFO)
PC12

Out-Edges 1

act(p(RGD:Ppp1ca)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 262)) View Subject | View Object

In NGF-exposed PC12 cells, Egr-1 activates Cdk5 to promote phosphorylation of tau and inactivates PP1 via phosphorylation. Cdk5 phosphorylates Ser(396/404) directly. By phosphorylating and inactivating PP1, Cdk5 promotes tau phosphorylation at Ser(262) indirectly. PubMed:21489990

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
PC12

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.