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a(PUBCHEM:877863)

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Entity

Name
877863
Namespace
PUBCHEM
Namespace Version
None
Pattern
^\d+$

Appears in Networks 1

The Biology of Proteostasis in Aging and Disease v1.0.0

In-Edges 1

composite(a(CHEBI:sirolimus), a(PUBCHEM:877863)) hasComponent a(PUBCHEM:877863) View Subject | View Object

Appears in Networks:

Out-Edges 3

a(PUBCHEM:877863) increases bp(GO:autophagy) View Subject | View Object

A screen for autophagy inducers in yeast identified the molecules SMER-10, -18, and -28 as TOR-independent activators of autophagy (146). PubMed:25784053

Appears in Networks:
Annotations
Cell Ontology (CL)
motor neuron

a(PUBCHEM:877863) decreases p(HGNC:SNCA, var("p.Ala53Thr")) View Subject | View Object

Treatment of PC12 cells stably expressing mutant α-synuclein (A53T) with SMER-10, -18, or-28 significantly reduced levels of mutant α-synuclein, an effect that was enhanced by cotreatment with rapamycin (146). PubMed:25784053

Appears in Networks:
Annotations
Cell Ontology (CL)
motor neuron

a(PUBCHEM:877863) decreases a(HBP:"huntingtin aggregates") View Subject | View Object

In addition, SMER-10, -18, and -28 were effective at suppressing mHTT aggregation and toxicity in COS-7 cells and flies (146). PubMed:25784053

Appears in Networks:
Annotations
Cell Ontology (CL)
motor neuron

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.