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p(HGNC:HDAC3)

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Entity

Name
HDAC3
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Screening of a neuronal cell model of Tau pathology for therapeutic compounds v1.0.0

In-Edges 2

a(HBP:RGFP966) directlyDecreases act(p(HGNC:HDAC3)) View Subject | View Object

RGFP966, a selective HDAC3 inhibitor, has been shown to affect sensory cortical plasticity and memory formation (Bieszczad et al., 2015). PubMed:28771976

Appears in Networks:

a(PUBCHEM:4261) association p(HGNC:HDAC3) View Subject | View Object

Tab. 1A-B: Summary of the Tau aggregation modulators (inhibitors = 18 (A), stimulators = 10 (B)) which show decrease / increase in the amount of ThS + cells without affecting the expression level of TauRD∆K compared to the compound untreated control. PubMed:30640040

Appears in Networks:

Out-Edges 4

p(HGNC:HDAC3) decreases a(GO:"dendritic spine") View Subject | View Object

HDAC3 overexpression in the hippocampus increases Aß levels, activates microglia, and decreases dendritic spine density in 6-month-old APP/PS1 mice. PubMed:28771976

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(HGNC:HDAC3) increases act(a(CL:0000129)) View Subject | View Object

HDAC3 overexpression in the hippocampus increases Aß levels, activates microglia, and decreases dendritic spine density in 6-month-old APP/PS1 mice. PubMed:28771976

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(HGNC:HDAC3) increases a(CHEBI:"amyloid-beta") View Subject | View Object

HDAC3 overexpression in the hippocampus increases Aß levels, activates microglia, and decreases dendritic spine density in 6-month-old APP/PS1 mice. PubMed:28771976

Appears in Networks:
Annotations
Uberon
hippocampal formation

p(HGNC:HDAC3) association a(PUBCHEM:4261) View Subject | View Object

Tab. 1A-B: Summary of the Tau aggregation modulators (inhibitors = 18 (A), stimulators = 10 (B)) which show decrease / increase in the amount of ThS + cells without affecting the expression level of TauRD∆K compared to the compound untreated control. PubMed:30640040

Appears in Networks:

About

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.