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a(CHEBI:"GW 3965")

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Entity

Name
GW 3965
Namespace
chebi
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/chebi-names.belns

Appears in Networks 1

Nuclear receptors as therapeutic targets for Alzheimer's disease. v1.0.0

In-Edges 0

Out-Edges 9

a(CHEBI:"GW 3965") directlyIncreases act(p(HGNC:NR1H3)) View Subject | View Object

Importantly, this study utilized the LXR agonist, GW3965, to activate the LXRs and induce the expression of both ApoE and ABCA1. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

a(CHEBI:"GW 3965") increases act(p(HGNC:NR1H3)) View Subject | View Object

Similarly, stimulation of microglia with the LXR agonist, GW3965, acts simultaneously to suppress inflammation and promote fibrillar Ab stimulated phagocytosis [47]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
Medium

a(CHEBI:"GW 3965") increases p(HGNC:APOE) View Subject | View Object

Importantly, this study utilized the LXR agonist, GW3965, to activate the LXRs and induce the expression of both ApoE and ABCA1. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

a(CHEBI:"GW 3965") increases p(HGNC:ABCA1) View Subject | View Object

Importantly, this study utilized the LXR agonist, GW3965, to activate the LXRs and induce the expression of both ApoE and ABCA1. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

a(CHEBI:"GW 3965") decreases a(HBP:HBP00018) View Subject | View Object

Significantly, a 4-month treatment of Tg2576 mice with GW3965 reduced plaque deposition by > 50% and improved contextual memory in these animals [13]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

a(CHEBI:"GW 3965") increases bp(GO:memory) View Subject | View Object

Significantly, a 4-month treatment of Tg2576 mice with GW3965 reduced plaque deposition by > 50% and improved contextual memory in these animals [13]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

a(CHEBI:"GW 3965") decreases path(MESH:Inflammation) View Subject | View Object

Similarly, stimulation of microglia with the LXR agonist, GW3965, acts simultaneously to suppress inflammation and promote fibrillar Ab stimulated phagocytosis [47]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
Medium

a(CHEBI:"GW 3965") increases act(a(HBP:HBP00038)) View Subject | View Object

Similarly, stimulation of microglia with the LXR agonist, GW3965, acts simultaneously to suppress inflammation and promote fibrillar Ab stimulated phagocytosis [47]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
Medium

a(CHEBI:"GW 3965") increases bp(GO:phagocytosis) View Subject | View Object

Similarly, stimulation of microglia with the LXR agonist, GW3965, acts simultaneously to suppress inflammation and promote fibrillar Ab stimulated phagocytosis [47]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
Medium

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.