Evidences path(MESH:Anemia) to r(MGI:Epo)

During anemia (n  6), kidney EPO mRNA transcription increased 20-fold relative to control mice (n  5, P  0.001; Fig. 9A).

Heart EPO mRNA transcription was not significantly different in anemic mice relative to control mice (P  0.35).

Despite the preserved tissue PO2 level during subacute anemia, we demonstrated an increase in HIF-dependent mRNA levels of EPO, HO-1, and GAPDH. This finding is consistent with other experimental studies that have also demonstrated increases in HIF-dependent mRNA expression in the absence of a clear reduction in brain PtO2 (12, 23).

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.