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p(MGI:Mapt, pmod(Ph, Ser, 214), var("p.P301S"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Mapt
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0

In-Edges 2

bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(Ph, Ser, 214), var("p.P301S")) View Subject | View Object

In a mouse model expressing the FTDP-17 mutant P301S, promoting autophagy with trehalose treatment beginning at weaning significantly reduced insoluble tau, as well as tau phosphorylated at T212/S214 (AT100) (97). However, no other phosphorylation sites were assessed. This effect was correlated with improved neuronal survival in cortical layers I–III (97). PubMed:24027553

Appears in Networks:
Annotations
MeSH
Frontotemporal Dementia
Text Location
Review

p(MGI:Mapt) hasVariant p(MGI:Mapt, pmod(Ph, Ser, 214), var("p.P301S")) View Subject | View Object

Appears in Networks:

Out-Edges 0

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.