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p(HGNC:CAMKK2)

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Entity

Name
CAMKK2
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0

New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases v1.0.0

In-Edges 2

a(CHEBI:resveratrol) increases act(p(HGNC:CAMKK2)) View Subject | View Object

The ‘anti-ageing’ agent resveratrol is thought to indi- rectly recruit AMPK via activation of calcium/calmodulin- dependent protein kinase kinase 2 (CAMKK2), which, acting in synergy with Ca 2+ , exerts its effects via Thr172 phosphorylation 113 . This action, among others (below), is involved in its reduction of Aβ levels in N2a cells and neurons 114 and the elimination of Aβ and Htt in animal models of AD and HD 114,115 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons

composite(a(CHEBI:"calcium(2+)"), p(HGNC:CAMKK2)) hasComponent p(HGNC:CAMKK2) View Subject | View Object

Appears in Networks:

Out-Edges 4

p(HGNC:CAMKK2) increases act(p(HGNC:PSMC5)) View Subject | View Object

Another kinase that activates the proteasome (RPT6 subunit) — and directs it to dendritic spines — is CAMKK2 (REF.227) . PubMed:30116051

Appears in Networks:

act(p(HGNC:CAMKK2), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Activation of the CAMMK2 pathway has been shown to cause tau proteins to be phosphorylated PubMed:30663117

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

act(p(HGNC:CAMKK2), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

By activating the CAMMK2 pathway, the β‐ameloid can aid in the phosphorylation of tau proteins and eventually trigger tangles neurofibrillary. PubMed:30663117

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:CAMKK2) increases act(a(CHEBI:"amyloid-beta")) View Subject | View Object

By activating the CAMMK2 pathway, the β‐ameloid can aid in the phosphorylation of tau proteins and eventually trigger tangles neurofibrillary. PubMed:30663117

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.