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bp(GO:"cholesterol homeostasis")

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Entity

Name
cholesterol homeostasis
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 2

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

Nuclear receptors as therapeutic targets for Alzheimer's disease. v1.0.0

In-Edges 2

a(CHEBI:simvastatin) regulates bp(GO:"cholesterol homeostasis") View Subject | View Object

Simvastatin (SV) is a statin commonly used in the clinic to control cholesterol levels and it was shown to improve cognitive function in AD patients (Simons et al., 2002; Sparks et al., 2006) PubMed:25514383

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

p(HGNC:NR1H3) association bp(GO:"cholesterol homeostasis") View Subject | View Object

LXR receptors are activated by oxysterols, most prominently hydroxylated forms of cholesterol, and play a critical role in the control of whole body cholesterol homeostasis, as well as exerting potent anti-inflammatory actions [26]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

Out-Edges 1

bp(GO:"cholesterol homeostasis") association p(HGNC:NR1H3) View Subject | View Object

LXR receptors are activated by oxysterols, most prominently hydroxylated forms of cholesterol, and play a critical role in the control of whole body cholesterol homeostasis, as well as exerting potent anti-inflammatory actions [26]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.