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complex(p(HGNC:NGF), p(HGNC:NGFR))

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Components

Appears in Networks 1

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

In-Edges 0

Out-Edges 3

complex(p(HGNC:NGF), p(HGNC:NGFR)) hasComponent p(HGNC:NGF) View Subject | View Object

Appears in Networks:

complex(p(HGNC:NGF), p(HGNC:NGFR)) hasComponent p(HGNC:NGFR) View Subject | View Object

Appears in Networks:

complex(p(HGNC:NGF), p(HGNC:NGFR)) increases complex(p(HGNC:NGF), p(HGNC:NTRK1)) View Subject | View Object

NGF is synthesized as a precursor (proNGF) molecule that is proteolytically cleaved to a mature biologically active neurotrophin peptide [49]. Mature NGF binds to the TrkA receptor, which stimulates signal transduction pathways mediating the majority of the survival and growth effects of NGF [50], and to the p75NTR receptor, which is a positive modulator of NGF/TrkA binding [50]. However, p75NTR has multiple functions, including apoptotic or cell death actions [51–56], which are dependent upon its interaction with various receptor chaperones [57–59]. PubMed:18986241

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MeSH
Cognitive Dysfunction

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.