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p(HGNC:SLC12A5)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
SLC12A5
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses v1.0.0

In-Edges 2

a(HBP:"alpha-7-containing nAChR") increases p(HGNC:SLC12A5) View Subject | View Object

One important role for alpha7 nAChRs, in conjunction with alpha3-containing nAChRs, is the induction of the KCC2 chloride transporter in pyramidal neurons (Liu et al., 2006) PubMed:21482353

Appears in Networks:
Annotations
MeSH
Pyramidal Cells

a(HBP:"alpha-7-containing nAChR") increases p(HGNC:SLC12A5) View Subject | View Object

A specific role of alpha7 nAChRs was demonstrated by failure of the induction of KCC2 by treatment with alpha7 nAChR antagonists and in a7 KO mice (Zhang and Berg, 2007) PubMed:21482353

Appears in Networks:

Out-Edges 2

p(HGNC:SLC12A5) decreases a(CHEBI:chloride) View Subject | View Object

This transporter lowers the internal Cl- concentration of the neuron and changes GABA from a depolarizing to a hyperpolarizing or inhibitory neurotransmitter PubMed:21482353

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:SLC12A5) regulates act(a(CHEBI:"gamma-aminobutyric acid")) View Subject | View Object

This transporter lowers the internal Cl- concentration of the neuron and changes GABA from a depolarizing to a hyperpolarizing or inhibitory neurotransmitter PubMed:21482353

Appears in Networks:
Annotations
MeSH
Neurons

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.