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p(HGNC:CDK4)

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Entity

Name
CDK4
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways v1.0.0

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs) v1.0.1

In-Edges 3

complex(p(HGNC:CDC37), p(HGNC:CDK4)) hasComponent p(HGNC:CDK4) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CDK4), p(HGNC:FKBP5)) hasComponent p(HGNC:CDK4) View Subject | View Object

Appears in Networks:

a(CHEBI:palbociclib) decreases act(p(HGNC:CDK4)) View Subject | View Object

In line with these observations a small molecule inhibitor of CDK4/6 that causes a stall in G1 phase (PD0332991) was sufficient to almost double the amount of tau taken up in H4 cells (Supplementary Fig. 2e) PubMed:29686391

Appears in Networks:

Out-Edges 1

p(HGNC:CDK4) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) View Subject | View Object

In line with these observations a small molecule inhibitor of CDK4/6 that causes a stall in G1 phase (PD0332991) was sufficient to almost double the amount of tau taken up in H4 cells (Supplementary Fig. 2e) PubMed:29686391

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.