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complex(a(CHEBI:nicotine), p(FPLX:CHRN))

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Components

Appears in Networks 3

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

Nicotinic Receptor Abnormalities of Alzheimer’s Disease: Therapeutic Implications v1.0.0

In-Edges 4

path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) View Subject | View Object

Binding studies performed with the use of [3H]-nicotine and [3H]-ACh showed a significant reduction in nicotine and ACh binding sites in cerebral cortex of patients suffering from AD, demonstrating a decrease of both nAChR and mAChR populations (Gotti et al., 2006a; Paterson and Nordberg, 2000; Perry et al., 1981, 1985, 1987, 1988; Shimohama et al., 1986; Whitehouse et al., 1981, 1982, 1986) PubMed:25514383

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Annotations
MeSH
Cerebral Cortex

a(MESH:"Nerve Growth Factor") increases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) View Subject | View Object

Nerve growth factor intraventricularly administered to AD patients for 3 months resulted in an increased [11C]nicotine binding (Eriksdotter-Jo¨nhagen et al 1998), whereas treatment with the 5-HT3 blocker ondansetron showed a decreased number of cortical nAChRs (Nordberg et al 1997) PubMed:11230871

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Annotations
MeSH
Alzheimer Disease

bp(GO:cognition) association complex(a(CHEBI:nicotine), p(FPLX:CHRN)) View Subject | View Object

A significant correlation can be observed between cognitive function and nicotinic receptor binding (k2*) (Figure 3A) PubMed:11230871

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) View Subject | View Object

Selective cortical deficits in [11C]nicotine binding are often observed by PET early in the course of the AD disease (Figure 3A) PubMed:11230871

Appears in Networks:

Out-Edges 4

complex(a(CHEBI:nicotine), p(FPLX:CHRN)) hasComponent a(CHEBI:nicotine) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:nicotine), p(FPLX:CHRN)) hasComponent p(FPLX:CHRN) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:nicotine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) View Subject | View Object

Not only nicotine, but also DMPP (1,1-Dimethyl-4- phenylpiperazinium) and cystine can act as nicotinic receptor agonists PubMed:26813123

Appears in Networks:

complex(a(CHEBI:nicotine), p(FPLX:CHRN)) association bp(GO:cognition) View Subject | View Object

A significant correlation can be observed between cognitive function and nicotinic receptor binding (k2*) (Figure 3A) PubMed:11230871

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.