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complex(a(HBP:"protein aggregates"), a(MESH:Neurons))

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Components

Appears in Networks 1

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

In-Edges 1

p(HGNC:UBE3A) increases complex(a(HBP:"protein aggregates"), a(MESH:Neurons)) View Subject | View Object

Further supporting this hypothesis is the finding of Cummings and collaborators (Cummings et al., 1999) that inactivation of the gene coding for the E6-AP (Ube3a) ligase in a transgenic model of SCA-1 resulted in a reduced number of neurons containing intranuclear aggregates (see below). PubMed:14556719

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Out-Edges 2

complex(a(HBP:"protein aggregates"), a(MESH:Neurons)) hasComponent a(HBP:"protein aggregates") View Subject | View Object

Appears in Networks:

complex(a(HBP:"protein aggregates"), a(MESH:Neurons)) hasComponent a(MESH:Neurons) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.