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a(HBP:"4R tau")

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Entity

Name
4R tau
Namespace
HBP
Namespace Version
20181128
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/7e4be528f12abd28be768b62402fba6e083eaf9e/export/hbp-names.belns

Appears in Networks 1

Analysis of Isoform-specific Tau Aggregates Suggests a Common Toxic Mechanism Involving Similar Pathological Conformations and Axonal Transport Inhibition v1.0.1

In-Edges 6

a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"4R tau") View Subject | View Object

The band patterns in the immunoblots showed that the AD cases contained a mixture of isoforms, the PiD cases clearly contained 3R isoforms but also some 4R isoforms, while the vast majority of pathology in CBD cases were comprised of 4R tau isoforms PubMed:27574109

Appears in Networks:

bp(GO:"positive regulation of protein oligomerization") positiveCorrelation a(HBP:"4R tau") View Subject | View Object

A mixture of long, intermediate and short filaments, as well as globular oligomers were present in 4R isoform reactions (Fig. 2C–E) PubMed:27574109

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"4R tau") View Subject | View Object

The band patterns in the immunoblots showed that the AD cases contained a mixture of isoforms, the PiD cases clearly contained 3R isoforms but also some 4R isoforms, while the vast majority of pathology in CBD cases were comprised of 4R tau isoforms PubMed:27574109

Appears in Networks:

path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"4R tau") View Subject | View Object

The band patterns in the immunoblots showed that the AD cases contained a mixture of isoforms, the PiD cases clearly contained 3R isoforms but also some 4R isoforms, while the vast majority of pathology in CBD cases were comprised of 4R tau isoforms PubMed:27574109

Appears in Networks:

path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"4R tau") View Subject | View Object

Right angle laser light scattering showed significantly greater scattered light intensity in all 4R tau isoforms when compared to 3R isoforms (one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 60.22, p < 0.0001; Fig. 2A) PubMed:27574109

Appears in Networks:

path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"4R tau") View Subject | View Object

Similar results were seen in the ThS assay, where the 4R isoforms were significantly higher than 3R isoforms (one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 19.99, p < 0.0001; Fig. 2B), and no differences were found in comparisons between the individual 4R isoforms or between the 3R isoforms PubMed:27574109

Appears in Networks:

Out-Edges 6

a(HBP:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") View Subject | View Object

Right angle laser light scattering showed significantly greater scattered light intensity in all 4R tau isoforms when compared to 3R isoforms (one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 60.22, p < 0.0001; Fig. 2A) PubMed:27574109

Appears in Networks:

a(HBP:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") View Subject | View Object

Similar results were seen in the ThS assay, where the 4R isoforms were significantly higher than 3R isoforms (one-way ANOVA with Holm-Sidak post-hoc, F(5, 18) = 19.99, p < 0.0001; Fig. 2B), and no differences were found in comparisons between the individual 4R isoforms or between the 3R isoforms PubMed:27574109

Appears in Networks:

a(HBP:"4R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization") View Subject | View Object

A mixture of long, intermediate and short filaments, as well as globular oligomers were present in 4R isoform reactions (Fig. 2C–E) PubMed:27574109

Appears in Networks:

a(HBP:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

The band patterns in the immunoblots showed that the AD cases contained a mixture of isoforms, the PiD cases clearly contained 3R isoforms but also some 4R isoforms, while the vast majority of pathology in CBD cases were comprised of 4R tau isoforms PubMed:27574109

Appears in Networks:

a(HBP:"4R tau") positiveCorrelation path(MESH:"Pick Disease of the Brain") View Subject | View Object

The band patterns in the immunoblots showed that the AD cases contained a mixture of isoforms, the PiD cases clearly contained 3R isoforms but also some 4R isoforms, while the vast majority of pathology in CBD cases were comprised of 4R tau isoforms PubMed:27574109

Appears in Networks:

a(HBP:"4R tau") positiveCorrelation a(HBP:"Corticobasal Degeneration") View Subject | View Object

The band patterns in the immunoblots showed that the AD cases contained a mixture of isoforms, the PiD cases clearly contained 3R isoforms but also some 4R isoforms, while the vast majority of pathology in CBD cases were comprised of 4R tau isoforms PubMed:27574109

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.