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p(MGI:Sirt3)

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Entity

Name
Sirt3
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 4

p(HGNC:MAPT) negativeCorrelation p(MGI:Sirt3) View Subject | View Object

After pretreating hTau neurons with oligo Aβ-42 (1000 ng/ml), Sirt3 levels were reduced (Fig. 6b and e). This reduction in Sirt3 was translated into an increase in total tau and Ac-tau. PubMed:29540553

Appears in Networks:

p(HGNC:APP, frag("672_713")) negativeCorrelation p(MGI:Sirt3) View Subject | View Object

After pretreating hTau neurons with oligo Aβ-42 (1000 ng/ml), Sirt3 levels were reduced (Fig. 6b and e). This reduction in Sirt3 was translated into an increase in total tau and Ac-tau. PubMed:29540553

Appears in Networks:

p(HGNC:MAPT, pmod(Ac)) negativeCorrelation p(MGI:Sirt3) View Subject | View Object

After pretreating hTau neurons with oligo Aβ-42 (1000 ng/ml), Sirt3 levels were reduced (Fig. 6b and e). This reduction in Sirt3 was translated into an increase in total tau and Ac-tau. PubMed:29540553

Appears in Networks:

path(MESH:"Alzheimer Disease") negativeCorrelation p(MGI:Sirt3) View Subject | View Object

Sirt3 levels were reduced in the entorhinal cortex, the middle temporal gyrus, and the superior frontal gyrus of AD subjects compared to those of CN and was associated with poorer test scores of neuropsychological evaluation and the severity of tau pathology. PubMed:29540553

Appears in Networks:
Annotations
Uberon
entorhinal cortex
Uberon
middle temporal gyrus
Uberon
superior frontal gyrus

Out-Edges 4

p(MGI:Sirt3) negativeCorrelation p(HGNC:APP, frag("672_713")) View Subject | View Object

After pretreating hTau neurons with oligo Aβ-42 (1000 ng/ml), Sirt3 levels were reduced (Fig. 6b and e). This reduction in Sirt3 was translated into an increase in total tau and Ac-tau. PubMed:29540553

Appears in Networks:

p(MGI:Sirt3) negativeCorrelation p(HGNC:MAPT) View Subject | View Object

After pretreating hTau neurons with oligo Aβ-42 (1000 ng/ml), Sirt3 levels were reduced (Fig. 6b and e). This reduction in Sirt3 was translated into an increase in total tau and Ac-tau. PubMed:29540553

Appears in Networks:

p(MGI:Sirt3) negativeCorrelation p(HGNC:MAPT, pmod(Ac)) View Subject | View Object

After pretreating hTau neurons with oligo Aβ-42 (1000 ng/ml), Sirt3 levels were reduced (Fig. 6b and e). This reduction in Sirt3 was translated into an increase in total tau and Ac-tau. PubMed:29540553

Appears in Networks:

p(MGI:Sirt3) negativeCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Sirt3 levels were reduced in the entorhinal cortex, the middle temporal gyrus, and the superior frontal gyrus of AD subjects compared to those of CN and was associated with poorer test scores of neuropsychological evaluation and the severity of tau pathology. PubMed:29540553

Appears in Networks:
Annotations
Uberon
entorhinal cortex
Uberon
middle temporal gyrus
Uberon
superior frontal gyrus

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.