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p(HGNC:CHRNA7, var("p.Leu343Ala"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
CHRNA7
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Chaperoning α7 neuronal nicotinic acetylcholine receptors v1.0.0

In-Edges 1

p(HGNC:CHRNA7) hasVariant p(HGNC:CHRNA7, var("p.Leu343Ala")) View Subject | View Object

Appears in Networks:

Out-Edges 1

p(HGNC:CHRNA7, var("p.Leu343Ala")) decreases surf(p(HGNC:CHRNA7)) View Subject | View Object

A recent study showed that mutation of amino acids from this region (leucines 335, 336 or 343) to alanine reduced cell-surface expression of α7 AChRs [173]. PubMed:22040696

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.