bp(GO:"axonal transport of mitochondrion")
The velocity of mitochondrial transport in the pro-aggregant strain was lower than in wild-type (mean + SD ¼ 171 + 111 versus 256 + 117 nm/s), whereas the anti-aggregant strain (194 + 131 nm/ s) did not substantially differ from wild- type (Fig. 7D). PubMed:22611162
As a result, the proaggregant lines showed a range of defects including paralysis, axonal degeneration of GABAergic and cholinergic motor neurons, presynaptic defects, synapse loss, and mitochondrial transport defects early in adulthood PubMed:29191965
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.