rxn(reactants(p(HGNC:APP)), products(a(MESH:"Amyloid beta-Peptides")))

Three different proteases, called alpha, beta, and gamma secretases, can cleave APP at specific sites and generate products that are well characterized. PubMed:14556719

Concomitant cleavage of APP by beta and gamma secretase at specific sites can result in fragments (Abeta1-40 or Abeta1-42) that can misfold and form extracellular fibrils. PubMed:14556719

AVs are also enriched in APP substrates and secretases and, during autophagy, Ab peptide is generated from APP (Yu et al. 2005), although it is subsequently degraded in lysosomes under normal circumstances (Heinrich et al. 1999; Bahr et al. 2002; Florez-McClure et al. 2007). PubMed:22908190