Evidences p(MGI:"oncostatin M") to p(MGI:"signal transducer and activator of transcription 3")

NF-κB and STAT3 are the major transcription factors activated by IL-1 and OSM, respectively

OSM and IL-1 efficiently regulated YKL-40 expression via STAT3 (Fig. 3A) and OSM promoted the recruitment of IL-1-induced p50 to the YKL-40 promoter (Fig. 5B).

These data suggest that in addition to STAT3 activation, OSM enhances YKL-40 expression by promoting formation of the RelB/p50 complexes, which bind to the YKL-40 promoter

Constitutively active STAT3 enhanced, whereas dominant-negative IκBα diminished cytokine-responsiveness.

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.