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granular tau oligomers
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Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage from Shafiei et al., 2017

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a(HBP:"Tau oligomers") increases a(HBP:"granular tau oligomers") View Subject | View Object

When the oligomer lengthens, it adapts a beta-sheet structure and transforms into a detergent-insoluble aggregate with granular appearance under Atomic Force Microscopy (AFM) PubMed:28420982

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a(HBP:"granular tau oligomers") increases a(HBP:"Tau fibrils") View Subject | View Object

As these granular tau oligomers fuse together, they form tau fibrils, which ultimately form NFTs (Takashima, 2013) PubMed:28420982


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