granular tau oligomers

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Entity

Name: granular tau oligomers
Namespace: HBP
Namespace Version: 20181023
Namespace URL: https://raw.githubusercontent.com/pharmacome/terminology/3074b85b858455d8eeb76cfcdef685ced19bbe11/export/hbp-names.belns

Appears in Networks 1

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage from Shafiei et al., 2017

In-Edges 1

a(HBP:"Tau oligomers") increases a(HBP:"granular tau oligomers") View Subject | View Object

When the oligomer lengthens, it adapts a beta-sheet structure and transforms into a detergent-insoluble aggregate with granular appearance under Atomic Force Microscopy (AFM) PubMed:28420982

Appears in Networks:

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0

Annotations

Confidence: Medium
MeSH: Cerebral Cortex

Out-Edges 1

a(HBP:"granular tau oligomers") increases a(HBP:"Tau fibrils") View Subject | View Object

As these granular tau oligomers fuse together, they form tau fibrils, which ultimately form NFTs (Takashima, 2013) PubMed:28420982

Appears in Networks:

Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0

Annotations

Confidence: Medium
MeSH: Cerebral Cortex

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.