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a(CHEBI:stattic)

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Entity

Name
stattic
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation v1.0.0

In-Edges 0

Out-Edges 4

a(CHEBI:stattic) decreases p(HGNC:STAT3, pmod(Ph)) View Subject | View Object

As a positive control, we used stattic, a known inhibitor of STAT3 dimerization and phosphorylation PubMed:23178521

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
SH-SY5Y

a(CHEBI:stattic) decreases p(HGNC:STAT3, pmod(Ph)) View Subject | View Object

We found that stattic inhibited STAT3 phosphorylation (Mann–Whitney U=0, Z=-2.324, P=0.02) and also suppressed p65 NFkB phosphorylation (Mann–Whitney U¼0, Z¼2.324, P¼0.02) mimicking the effect of anatabine in SHSY5Y cells (Fig. 1) PubMed:23178521

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
SH-SY5Y

a(CHEBI:stattic) decreases complex(p(HGNC:STAT3), p(HGNC:STAT3)) View Subject | View Object

As a positive control, we used stattic, a known inhibitor of STAT3 dimerization and phosphorylation PubMed:23178521

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
SH-SY5Y

a(CHEBI:stattic) decreases p(HGNC:RELA, pmod(Ph)) View Subject | View Object

We found that stattic inhibited STAT3 phosphorylation (Mann–Whitney U=0, Z=-2.324, P=0.02) and also suppressed p65 NFkB phosphorylation (Mann–Whitney U¼0, Z¼2.324, P¼0.02) mimicking the effect of anatabine in SHSY5Y cells (Fig. 1) PubMed:23178521

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
SH-SY5Y

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.