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p(HGNC:PARK7)

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Entity

Name
PARK7
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases v1.0.0

In-Edges 7

bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PARK7)) View Subject | View Object

Miller and colleagues (Miller et al., 2003) have recently shown that this mutation destabilizes DJ-1 via promotion of its rapid, UPS-mediated degradation PubMed:14556719

Appears in Networks:

complex(p(HGNC:PARK7), p(HGNC:PIAS2)) hasComponent p(HGNC:PARK7) View Subject | View Object

Appears in Networks:

p(HGNC:PARK7, pmod(Sumo)) regulates act(p(HGNC:PARK7)) View Subject | View Object

DJ-1 activity may be regulated by SUMOylation, as it was found that it binds to the SUMO E3 PIASx (Takahashi et al., 2001). PubMed:14556719

Appears in Networks:

p(HGNC:PARK7, var("p.Leu166Pro")) increases deg(p(HGNC:PARK7)) View Subject | View Object

Miller and colleagues (Miller et al., 2003) have recently shown that this mutation destabilizes DJ-1 via promotion of its rapid, UPS-mediated degradation PubMed:14556719

Appears in Networks:

g(HGNC:MIR34B) increases p(HGNC:PARK7) View Subject | View Object

In addition, miR‐34‐b and miR‐34‐c have been shown to experience a significant reduction in patients with Parkinson’s compared with controls, and this reduction is accompanied by a decrease in the expression of DJ‐1 protein PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

g(HGNC:MIR34C) increases p(HGNC:PARK7) View Subject | View Object

In addition, miR‐34‐b and miR‐34‐c have been shown to experience a significant reduction in patients with Parkinson’s compared with controls, and this reduction is accompanied by a decrease in the expression of DJ‐1 protein PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

path(MESH:"Parkinson Disease") decreases p(HGNC:PARK7) View Subject | View Object

It has been shown that DJ‐1 protein levels in patients with PD are significantly lower compared with the healthy subjects PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

Out-Edges 5

p(HGNC:PARK7) hasVariant p(HGNC:PARK7, pmod(Sumo)) View Subject | View Object

Appears in Networks:

p(HGNC:PARK7) hasVariant p(HGNC:PARK7, var("p.Leu166Pro")) View Subject | View Object

Appears in Networks:

p(HGNC:PARK7) decreases a(HBP:"alpha-synuclein aggregates") View Subject | View Object

The PARK 7 gene on chromosome 1 is responsible for coding the DJ‐1 protein. This protein acts as chaperon in the neurons, thus preventing the aggregation of the α‐synuclein protein PubMed:30663117

Appears in Networks:
Annotations
MeSH
Neurons
MeSH
Parkinson Disease

p(HGNC:PARK7) decreases bp(GO:"apoptotic process") View Subject | View Object

It also inhibits apoptosis and prevents the death of neuron PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

p(HGNC:PARK7) decreases bp(GO:"neuron death") View Subject | View Object

It also inhibits apoptosis and prevents the death of neuron PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.