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bp(GO:"GO:0060384")

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Entity

Name
GO:0060384
Namespace
go
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/go.belns

Appears in Networks 1

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

In-Edges 3

a(MESH:D059329) directlyIncreases bp(GO:"GO:0060384") View Subject | View Object

Cholinergic neurons within the nucleus basalis (NB) and the septal diagonal band complex provide the major source of cholinergic innervation to the cerebral cortex and hippocampus, respectively, and play a key role in memory and attentional function [11–13]. PubMed:18986241

Appears in Networks:
Annotations
MeSH
Basal Nucleus of Meynert
MeSH
Cerebral Cortex
MeSH
Hippocampus

p(HGNC:NGF) association bp(GO:"GO:0060384") View Subject | View Object

In addition, indirect effects and unwanted side effects appeared with systemic administration including unregulated neurotransmitter release, hyperinnervation, sprouting of neurons, sympathetic stimulation, induction of antibodies, cachexia and hyperalgesia [178–181]. PubMed:18986241

Appears in Networks:
Annotations
MeSH
Cognitive Dysfunction

act(p(HGNC:GAL)) increases bp(GO:"GO:0060384") View Subject | View Object

For example, the neuropeptide GAL, which functions via the interaction with three G protein-coupled receptors termed GALR1, GALR2 and GALR3, has multiple biological actions, including effects on cognition and neuroplasticity [15,146,147]. In the late [148–150] but not early [151] stage of AD, fibers within the basal forebrain containing the neuropeptide GAL thicken and hyperinnervate surviving CBF neurons. Although animal and cell-culture studies have shown that GAL plays a crucial role in the regulation of CBF neuron activity [152] and rescues cholinergic cells from amyloid toxicity [153], the molecular consequences of this unique plasticity response upon CBF neurons in AD remain unclear. Gene expression studies of cholinergic transcripts have shown that GAL hyperinnervated, but not nonhyperinnervated, CBF neurons display an upregulation of ChAT expression in AD compared to controls [126] PubMed:18986241

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease
MeSH
Basal Forebrain
MeSH
Cholinergic Neurons
MeSH
Cognitive Dysfunction

Out-Edges 1

bp(GO:"GO:0060384") association p(HGNC:NGF) View Subject | View Object

In addition, indirect effects and unwanted side effects appeared with systemic administration including unregulated neurotransmitter release, hyperinnervation, sprouting of neurons, sympathetic stimulation, induction of antibodies, cachexia and hyperalgesia [178–181]. PubMed:18986241

Appears in Networks:
Annotations
MeSH
Cognitive Dysfunction

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.