complex(p(HGNC:HSPD1), p(HGNC:HSPE1))

Components

• p(HGNC:HSPD1)
• p(HGNC:HSPE1)

GroEL and GroES undergo a complex binding-and-release cycle that is allosterically regulated by ATP binding and hydrolysis in the GroEL subunits (Figure 6b) (4, 77, 100, 136). PubMed:23746257

Cooperative binding of ATP to GroEL initiates a series of conformational changes that trigger the association of GroES, followed by substrate release from hydrophobic binding sites into a GroES-capped, hydrophilic folding chamber (137). PubMed:23746257

Binding to GroEL prevents aggregation of these flexible folding intermediates, and subsequent folding depends critically on the global encapsulation of the substrate in the chaperonin cavity by the cochaperone GroES (7, 132–135). PubMed:23746257