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p(HGNC:DNM2)

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Entity

Name
DNM2
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs) v1.0.1

In-Edges 0

Out-Edges 3

p(HGNC:DNM2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) View Subject | View Object

These single gene knockdowns repressed uptake of tau monomer by over 50% (Fig. 2b) and also reduced the uptake of tau oligomers (Fig. 2c) PubMed:29686391

Appears in Networks:

p(HGNC:DNM2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) View Subject | View Object

Further, these gene knockdowns were sufficient to reduce the uptake of tau in iPS-derived neurons (Fig. 2d) PubMed:29686391

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:DNM2) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) View Subject | View Object

These single gene knockdowns repressed uptake of tau monomer by over 50% (Fig. 2b) and also reduced the uptake of tau oligomers (Fig. 2c) PubMed:29686391

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.