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p(HGNC:GSK3B, pmod(Ph, Ser, 404))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
GSK3B
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β. v1.0.0

In-Edges 3

p(HGNC:GSK3B) hasVariant p(HGNC:GSK3B, pmod(Ph, Ser, 404)) View Subject | View Object

Appears in Networks:

p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 404)) View Subject | View Object

The treatment of cortical neurons with compound C, a selective AMPK inhibitor (33), reduced the inhibitory phosphorylation of GSK3b at Ser9 and markedly increased tau phosphorylation at Ser396/404 PubMed:22419736

Appears in Networks:

p(ECCODE:"2.7.11.31") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 404)) View Subject | View Object

Conversely, treatment with AICAR (5-aminoimidazole-4- carboxamide ribonucleoside), an AMPK activator (34), increased the inhibitory phosphorylation of GSK3b and reduced tau phosphorylation at Ser396/404 in SH-SY5Y cells and cortical neurons PubMed:22419736

Appears in Networks:

Out-Edges 0

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.