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  3. complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family"))

complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family"))

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Components

Appears in Networks 2

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways v1.0.0

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies v1.0.0

In-Edges 1

p(HGNC:STUB1) directlyIncreases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) View Subject | View Object

CHIP binds Hsp90 and Hsp70 with similar affinities and can regulate the degradation of chaperone clients (Kundrat and Regan, 2010). PubMed:25036637

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Out-Edges 3

complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) hasComponent p(HGNC:STUB1) View Subject | View Object

Appears in Networks:

complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) hasComponent p(INTERPRO:"Heat shock protein 70 family") View Subject | View Object

Appears in Networks:

complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:MAPT)) View Subject | View Object

Hsp70 has been shown to both stabilize binding of tau to microtubules [114] and promote its degradation in combination with CHIP [115,116] PubMed:21882945

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.